Eggs start off with 46 chromosomes and need to undergo a process of shedding extra chromosomes to become a mature egg. For fertilization to properly occur, a healthy egg cell should have 23 chromosomes that can pair with the 23 chromosomes from a sperm cell. Very rarely, they can all be immature! If IVF is being done, all eggs are going to get inseminated as eggs are left in their fluffy cumulus cells and the next morning we will see which ones are fertilized.
Again, the immature ones will not fertilize. Of those mature eggs that are capable of fertilizing, they are not all expected to fertilize. Kristen may also see some that fertilize abnormally and need to be discarded.
With this being said, patients who had only a small fraction of their eggs fertilize, will get pregnant from those few embryos. Most fertilized eggs, or embryos as they now are, will divide onto a day 3 embryo ; as the cells divide, the quality may start to deteriorate, cell fragment, and may divide unevenly.
These embryos would not have been capable of forming a healthy pregnancy. A big drop in numbers usually occurs in the phase between day 3 and day 5 of embryo development.
We spend a lot of time in our office talking to patients about quality of eggs, embryos and blastocysts. This post is to provide some insight into the world of the laboratory and those microscopic cells that mean so much to us. Eggs, when they are retrieved during IVF or ovulated in the body, are all the same size. Follicle sizes may vary, but the eggs are all the same.
Some eggs that are recovered during IVF are immature meaning that they have not gone through their second meiotic division and cannot be fertilized by sperm or the result will be an embryo with too many chromosomes or degenerate meaning they are starting the process of dying off. The eggs come out in a halo of cells called the cumulus mass. The embryologist looks through the follicular fluid for this complex of cells and the egg under the microscope. It might be scary when we first go over the numbers together, but this is exactly how conception works in the natural process as well.
With IVF, we have the privilege of seeing this natural attrition happen in real time in a laboratory. As you may know by this point in your research, the first phase of IVF is to stimulate the ovaries and create as many dominant follicles as possible.
One becomes dominant and the rest are reabsorbed back into the body. That dominant follicle releases an egg into the fallopian tube during ovulation and is fertilized by sperm at that point. With IVF, we manipulate that normal cycle by getting as many of your follicles to grow into that dominant phase as possible instead of just the one. It takes a special mix of medications to make this happen, and when the growth phase is complete but before ovulation , we remove each egg from its follicle through a process called an egg retrieval.
Unfortunately, not all 12 eggs will be viable, or useable. Because only mature eggs will fertilize. While our goal is to have all mature eggs, they naturally grow at different paces and thus will leave us with some variation in viability. That leaves us with 10 viable eggs. The fertilization process has to happen naturally overnight with partner or donor sperm in a laboratory. This happens one of two ways: conventional insemination or ICSI. Is there anything you did?
Supplements or diet? Any advice? Congrats to you and best of luck. My name is Mira and 29 years old. My husband and I just started our IVF journey. I was diagnosed with PCOS at the age of I feel very nervous but my doctor seems very confident so it gives me peace of mind. So excited and scared at the same time. Hope it works out for us.
Please let me know as even I wear gng thro the same I am on day 6 of my cycle with gonal F injections. I am 31 years old from Singapore. I had 2 frozen day 5 blastocysts transferred yesterday 24oct This is my second ivf cycle. My first ivf cycle was 2 years ago and it was successful with 1 frozen day 5 blastocyst transferred. I will know my results on the 1st nov Wishing all the best to couples who are undergoing ivf now.
Any tips before or after treatment as in what to eat and what not to eat and etc? I had my blastocyst transfer on 13th july Now I have a negative result. On the day of transter after 5 hours I peed sitting on the floor.
Was it a mistake on my part? Is it avoidable after embryo transfer? I have no symptoms. It did not look like it was in blastocyst based on the picz online. It looks like a cell morula. Last was I am now 39yo and getting ready for ivf. I prefer blastocyst day5 embryo transfer than day2 embryo.
Do you think day5 is really better to have likely outcome than day2 embryo transfer? I am nervous really. I prefer to go day 5 blastocyst transfer. But my dr. Said she will do one day 3 embryo transfer nd one day 5 blastocyst transfer.
What do I do? Do I insist to do both blastocyst transfer? Hi was my first ivf and everything was good. My journey ivf. They said because off My age 41 now. So all my appointment was good scans. I had 2 good blastocyst put in last sun 10 days ago. Got test still this Friday. But I started to bleed monday. Got belly cramps. It feels like a period. That everything was good. Hello, I am turning 41 in a few days time, had 10 egg retrieval on the 16th may this year.
It was very exhausting and I had so much pain. I have been taking paracetamol as advised but I signed up for e-freeze trial as I had 8 fertilised eggs and 5 good embryones at day 3. I am pre-scheduled for a transfer this Sunday for a day 5 blastocyst in case I change my mind about the e-freeze. My husband and I talked about it and we decided to go for fresh transfer subject to my feeling ok on Sunday.
When I was informed by the embryologist that e-freeze has its own risk as there is a possibility that the egg may not survive the thawing process, it made me think twice about the e-freeze trial cos I thought,what was the point of paying so much for my IVF and then miss the opportunity for a fresh transfer when am not even sure if the embryo will survive the thawing process if frozen.
Just wondering, has anyone gone through the e-freeze trial for their first IVF? Many thanks. I think you have to go with your gut instinct maybe? Hi I had egg removal last year had 8 removed and all went under blastocyst.
So a year later I was ready to have transfer of 2 eggs. Both eggs defrosted well one egg described as very good and the other egg described as in good condition! Had both transferred on Thursday and now just having the long wait until I do the pregnancy test! Fingers crossed. I had a frozen transfer of one day 5 blastcyst in January I am now 25 weeks pregnancy.
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